Mitral Insufficiency Secondary to Mitral Valve Prolapse Due to Barlow’s Disease: A Case Report

Article Sidebar

PDF
Published: Mar 20, 2026
DOI: https://doi.org/10.47191/ijmscrs/v6-i3-21
Keywords:
Barlow’s disease, prolapse, regurgitation, surgical replacement, valve repair.

Main Article Content

Parra Mora Héctor Alejandro
Hospital Regional Valentín Gómez Farías, Zapopan, Jalisco Departamento de Cardiología Clínica.
Jiménez Galván Luz Elena
Hospital Regional Valentín Gómez Farías, Zapopan, Jalisco Departamento de Cardiología Clínica.
Morán Ramírez Fátima Guadalupe
Hospital Regional Valentín Gómez Farías, Zapopan, Jalisco Departamento de Cardiología Clínica.
Manríquez Vázquez Domingo Antonio
Hospital Regional Valentín Gómez Farías, Zapopan, Jalisco Departamento de Cardiología Clínica.
Jiménez López Carlos Eduardo
Hospital Regional Valentín Gómez Farías, Zapopan, Jalisco Departamento de Cardiología Clínica.

Abstract

Barlow’s disease is a common cause of primary degenerative mitral regurgitation. We present the case of a 61-year-old man with palpitations, dyspnea, and progressive fatigue. Echocardiography revealed an 11 mm mitral annular disjunction, bileaflet prolapse, posterior leaflet flail, and severe eccentric mitral regurgitation. After evaluation by the Heart Team, mitral valve replacement was indicated. Multimodal imaging enables adequate anatomical characterization and therapeutic planning, facilitating timely intervention and improving prognosis.

Article Details

How to Cite
Héctor Alejandro, Parra Mora, Jiménez Galván Luz Elena, Morán Ramírez Fátima Guadalupe, Manríquez Vázquez Domingo Antonio, and Jiménez López Carlos Eduardo. 2026. “Mitral Insufficiency Secondary to Mitral Valve Prolapse Due to Barlow’s Disease: A Case Report”. International Journal of Medical Science and Clinical Research Studies 6 (03):567-70. https://doi.org/10.47191/ijmscrs/v6-i3-21.
Issue
Vol. 6 No. 03 (2026): Volume 06 Issue 03 March 2026
Section
Articles
Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

References

I. Morales, C. A., Escalera, A., Salmerón, C., Hernández-Vaquero, D., Álvarez, R., Díaz, R., Mencía, P., Callejo, F., LLosa, J. C., Meana, B., Zabala, M., Morales, A., & Silva, J. A. (2022). Insuficiencia mitral en la enfermedad de Barlow. La mirada desde la reparación. Cirugía Cardiovascular, 29, S68-S73.

https://doi.org/10.1016/j.circv.2021.12.006

II. Rosas-Munive E, Valenzuela-Flores GA, Valenzuela-Flores AA. Prolapso valvular mitral. Revisión de la literatura. Cir Cir. 2004;72(5):415-420.

III. Chaudhari SS, Chokkalingam Mani B. Insuficiencia de la válvula mitral. En: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025.

IV. Pérez-Vázquez, S. I., Ladewig-Bérnaldez, G. I., González-Trueba, E. F., Mondragón-Morales, J., Hernández-Jiménez, M. G., García-Pérez, L. A., & Martínez-Guzmán, A. (2023). Barlow syndrome: a diagnostic difficulty. Revista Médica del Hospital General de México, 86(3).

https://doi.org/10.24875/hgmx.22000079

V. Hernandez-Vaquero, D., Díaz, R., & Silva, J. (2015). Peor supervivencia a largo plazo después de cirugía coronaria sin circulación extracorpórea que con ella. Cirugía Cardiovascular, 23(1), 59-60. https://doi.org/10.1016/j.circv.2015.08.003

VI. Rayudu NV. Mitral valve prolapse. Apollo Med. 2018;15:11-4.

VII. Wijngaarden, A. L. van, Kruithof, B. P. T., Vinella, T., Barge-Schaapveld, D. Q. C. M., & Marsan, N. A. (2021). Characterization of degenerative mitral valve disease: differences between fibroelastic deficiency and Barlow's disease. Journal Of Cardiovascular Development And Disease, 8(2). doi:10.3390/jcdd8020023

VIII. Suri RM, Vanoverschelde JL, Grigioni F, Schaff HV, Tribouilloy C, Avierinos JF, et al. Association between early surgical intervention vs watchful waiting and outcomes for mitral regurgitation due to flail mitral valve leaflets. JAMA. 2013;310:609-16.

IX. Butcher SC, Essayagh B, Steyerberg EW, Benfari G, Antoine C, Grigioni F, et al. Factors influencing post-surgical survival in degenerative mitral regurgitation. Eur Heart J. 2023;44:871-81.

X. Grigioni F, Clavel MA, Vanoverschelde JL, Tribouilloy C, Pizarro R, Huebner M, et al. The MIDA mortality risk score: development and external validation of a prognostic model for early and late death in degenerative mitral regurgitation. Eur Heart J. 2018;39:1281-91.

XI. Kavsur, R., Spieker, M., Iliadis, C., Metze, C., Transier, M., Tiyerili, V., Horn, P., Baldus, S., Kelm, M., Nickenig, G., Westenfeld, R., Pfister, R., Becher, M. U., & Rhineland, O. T. H. F. N. (2021). Mitral Regurgitation International Database (MIDA) Score Predicts Outcome in Patients With Heart Failure Undergoing Transcatheter Edge‐to‐Edge Mitral Valve Repair. Journal Of The American Heart Association, 10(13), e019548.

https://doi.org/10.1161/jaha.120.019548

XII. Hutchins, G. M., Moore, G. W., & Skoog, D. K. (1986). The Association of Floppy Mitral Valve with Disjunction of the Mitral Annulus Fibrosus. New England Journal Of Medicine, 314(9), 535-540.

https://doi.org/10.1056/nejm198602273140902

XIII. Borger, M. A., & Mohr, F. W. (2010). Repair of Bileaflet Prolapse in Barlow Syndrome. Seminars In Thoracic And Cardiovascular Surgery, 22(2), 174-178. https://doi.org/10.1053/j.semtcvs.2010.09.006

XIV. David, T. E., Ivanov, J., Armstrong, S., Christie, D., & Rakowski, H. (2005). A comparison of outcomes of mitral valve repair for degenerative disease with posterior, anterior, and bileaflet prolapse. Journal Of Thoracic And Cardiovascular Surgery, 130(5), 1242-1249.

https://doi.org/10.1016/j.jtcvs.2005.06.046