Effectivity of Vitamin D in Preventing Breast Cancer and Evaluation of 25(OH)D Examination As A Laboratory Screening Tool
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Abstract
Vitamin D is currently associated with many diseases, not only bone health but also in autoimmune diseases, cancer, and neurological disorders. This study focuses on the mechanism relation vitamin D on breast cancer, especially with regard to estrogen receptor-positive (ER+) and human epidermal growth factor receptor 2-positive (HER 2+) cancers. Therapeutic supplementation is a commonly used approach to increase vitamin D levels. The effects of vitamin D have been investigated in various aspects, including regulation of cell growth and differentiation, apoptosis, intercellular contact, angiogenesis, immune function, as well as interaction with gut microbiota. In this study, the effects of vitamin D on breast cancer and its relationship with serum 25(OH)D levels were also researched. As a result, patients newly diagnosed with breast cancer were found to have low serum 25(OH)D levels. Vitamin D administration has been shown to induce apoptosis in breast cancer cells.
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References
I. Henn M, Martin-Gorgojo V, Martin-Moreno JM. Vitamin D in Cancer Prevention: Gaps in Current Knowledge and Room for Hope. Vol. 14, Nutrients. MDPI; 2022.
II. Mackey JD, Young P, Zimmerer R, Miles B. 0559 Poster Session Vitamin D deficiency as a risk factor for breast cancer development. 2023.
III. Torres A, Cameselle C, Otero P, Simal-Gandara J. The Impact of Vitamin D and Its Dietary Supplementation in Breast Cancer Prevention: An Integrative Review. Vol. 16, Nutrients. Multidisciplinary Digital Publishing Institute (MDPI); 2024.
IV. Peila R, Xue X, Cauley JA, Chlebowski R, Manson JE, Nassir R, et al. A Randomized Trial of Calcium Plus Vitamin D Supplementation and Risk of Ductal Carcinoma in Situ of the Breast. JNCI Cancer Spectrum. 2021 Aug 1;5(4).
V. Khedmati Zare V, Javadi M, Amani-shalamzari S, Kaviani M. The high dose of vitamin D supplementation combined with yoga training improve the leukocytes cell survival-related gene expression in breast cancer survivors. Nutrition and Metabolism. 2021 Dec 1;18(1).
VI. Almassri HF, Abdul Kadir A, Srour M, Foo LH. The Effects of Omega-3 Fatty Acids and Vitamin D Supplementation on the Nutritional Status of Women with Breast Cancer in Palestine: An Open-Label Randomized Controlled Trial. Nutrients [Internet]. 2024 Nov 20;16(22):3960. Available from: https://www.mdpi.com/2072-6643/16/22/3960
VII. Zemlin C, Altmayer L, Stuhlert C, Schleicher JT, Wörmann C, Lang M, et al. Prevalence and Relevance of Vitamin D Deficiency in Newly Diagnosed Breast Cancer Patients: A Pilot Study. Nutrients. 2023 Mar 1;15(6).
VIII. Radom A, Wędrychowicz A, Pieczarkowski S, Skoczeń S, Tomasik P. Effect of selected factors on the serum 25(OH)D concentration in women treated for breast cancer. Nutrients. 2021 Feb 1;13(2):1–18.
IX. Tirgar A, Rezaei M, Ehsani M, Salmani Z, Rastegari A, Jafari E, et al. Exploring the synergistic effects of vitamin D and synbiotics on cytokines profile, and treatment response in breast cancer: a pilot randomized clinical trial. Scientific Reports. 2024 Dec 1;14(1).
X. Tattersall M. Cancer clinical trial recruitment: The emerging role and perspectives of clinical research associates and data managers. Vol. 95, Cancer. 2002. p. 1397–400.
XI. Chauhan K, Shahrokhi M, Huecker MR. Vitamin D. stat Pearl.2023 (quoted on March 2025) avaliable on: https://www.ncbi.nlm.nih.gov/books/NBK441912/
XII. Kim Y, Je Y. Vitamin D intake, blood 25(OH)D levels, and breast cancer risk or mortality: A meta-analysis. British Journal of Cancer. 2014 May 27;110(11):2772–84.
XIII. Muñoz A, Grant WB. Vitamin D and Cancer: An Historical Overview of the Epidemiology and Mechanisms. Vol. 14, Nutrients. MDPI; 2022.